منابع مشابه
Enzymatic Synthesis of Ribonucleic Acid
The discovery of enzymes which catalyze the deoxyribonucleic acid-dependent synthesis of ribopolynucleotides (l-6) stimulated an immediate inquiry into the role played by DNA in thisunique reaction. The speculation that DNA might serve as a template for the polymerization of ribonucleotides into a complementary ribonucleic acid molecule was confirmed by studies from a number of different groups...
متن کاملEnzymatic Synthesis of Ribonucleic Acid. I. Preparation of Ribonucleic Acid Polymerase from Extracts of Micrococcus Lysodeikticus.
The problem of complex polynucleotide synthesis has received considerable attention from numerous investigators (l-3). Grunberg-Manago and Ochoa (4) and Kornberg, Lehman, and Simms (5) first successfully demonstrated the polymerization in vitro of riboand deoxynucleotides with cell-free extracts from microorganisms. Subsequent studies on the synthesis of ribonucleic acid and deoxyribonucleic ac...
متن کاملThe Enzymatic Synthesis of Ribonucleic Acid. v. the Interaction of Ribonucleic Acid Polymerase with Nucleic Acids.
Numerous reports have been published on the properties and reaction mechanism of the highly purified enzyme preparations that catalyze the deoxyribonucleic acid-directed synthesis of ribonucleic acid (l-6). The various RNA polymerases tudied, although differing in some respects, show a remarkable similarity in their cofactor requirements, reaction kinetics, physical properties, and facility to ...
متن کاملEnzymatic Synthesis of Ribonucleic Acid 1. PREPARATION OF RIBONUCLEIC ACID POLYMERASE FROM EXTRACTS OF MICROCOCCUS LYSODEIKTICUP
The problem of complex polynucleotide synthesis has received considerable attention from numerous investigators (l-3). Grunberg-Manago and Ochoa (4) and Kornberg, Lehman, and Simms (5) first successfully demonstrated the polymerization in vitro of riboand deoxynucleotides with cell-free extracts from microorganisms. Subsequent studies on the synthesis of ribonucleic acid and deoxyribonucleic ac...
متن کاملEnzymatic Synthesis of Ribonucleic Acid. Iv. the Deoxyribonucleic Acid-directed Synthesis of Complementary Cytoplasmic Ribonucleic Acid Components.
The ribonucleic acid product formed by ribonucleic acid polymerase resembles its deoxyribonucleic acid template in base composition and in base sequence (l-6). The reaction in vitro results in the synthesis of RNA chains which are complementary to both DNA strands (6). Evidence for this originates from the formation of highly ordered RNA structures when the RNA polymerase product is annealed wi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1964
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)93836-6